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K. D. Welch, J. A. Pfister, D. R. Gardner, B. T. Green and K. E. Panter The role of the α7 subunit of the nicotinic acetylcholine receptor on motor coordination in mice treated with methyllycaconitine and anabasine Journal of Applied Toxicology 33

Article first published online: 24 MAY 2013 | DOI: 10.1002/jat.2894

The objective of this study was to determine if α7 nAChR subunits play a role in the motor coordination deficiencies elicited by nAChR agonists and antagonists by comparing the motor function and coordination of wild-type mice to mice lacking the α7 nAChR subunit after exposure to a non-lethal dose of methyllycaconitine (MLA) or anabasine. The results from this study suggest that the α7 nAChR does not play an integral role in the motor coordination of mice.

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