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Anne-Marie Saillenfait, Jean-Philippe Sabaté, Alain Robert, Virginie Rouiller-Fabre, Alain-Claude Roudot, Delphine Moison and Flavien Denis Dose-dependent alterations in gene expression and testosterone production in fetal rat testis after exposure to di-n-hexyl phthalate Journal of Applied Toxicology 33

Article first published online: 11 JUN 2013 | DOI: 10.1002/jat.2896

Pregnant Sprague–Dawley rats were administered di-n-hexyl phthalate (DnHP) at a broad range of doses (5 to 625 mg kg–1 per day) or DEHP (50 or 625 mg kg–1 per day), by gavage, from gestation day (GD) 12 to 19. A decrease in ex vivo testosterone production by GD 19 fetal testis was observed at doses of 20 mg kg–1 per day and higher. Accordingly, DnHP reduced the expression of several genes involved in steroid synthesis pathway (SRB1, StAR, P450scc, 3βHSD and P450c17) in a dose-dependent manner.

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