Rebecca J. Dearman, Lorna Beresford, Emily S. Foster, Scott McClain and Ian Kimber Characterization of the allergenic potential of proteins: an assessment of the kiwifruit allergen actinidin Journal of Applied Toxicology 34
Potential allergenicity is an important challenge in the safety assessment of novel foods. Resistance to pepsin digestion is commonly measured, although the association is not absolute. The ability of kiwifruit actinidin (an important new allergen) to stimulate antibody responses in BALB/c mice was compared with the reference allergen ovalbumin, and the non-allergen bovine haemoglobin. Actinidin, but not haemoglobin, displays marked IgE responses, suggesting that in tandem with pepsin stability, IgE measurement may be useful for protein allergen identification.
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