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Baoyong Sha, Wei Gao, Shuqi Wang, Xingchun Gou, Wei Li, Xuan Liang, Zhiguo Qu, Feng Xu and Tian Jian Lu Oxidative stress increased hepatotoxicity induced by nano-titanium dioxide in BRL-3A cells and Sprague–Dawley rats Journal of Applied Toxicology 34

Version of Record online: 22 JUL 2013 | DOI: 10.1002/jat.2900

Nanotoxicity assessment of titanium dioxide (TiO2) under oxidative stress (OS) conditions is a novel field. Compared with nanomaterials (NMs) exposure only, OS conditions and nano-TiO2 synergistically reduced BRL-3A cell viabilities and resulted in the rapid G0/G1 to S phase transition and G2/M arrest. Interactions between OS conditions and nano-TiO2 induced obvious pathological changes in rat livers and enhanced the activities of liver damage biomarkers.

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