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Linlong Wang, Yunpeng Wu, Yang Tan, Xi Fei, Yu Deng, Hong Cao, Biao Chen, Hui Wang, Jacques Magdalou and Liaobin Chen Cytotoxic effects of the quinolone levofloxacin on rabbit meniscus cells Journal of Applied Toxicology 34

Version of Record online: 1 JUL 2013 | DOI: 10.1002/jat.2903

Rabbit meniscus cells were administrated with different concentrations of levofloxacin. After treatment with levofloxacin for 48 h, cells viability was decreased and apoptotic cells increased. Meanwhile, active caspase-3 protein expression level was also increased and mRNA expression level of Bcl-2 decreased. Both mRNA and protein expression levels of MMP-3 and MMP-13 increased. Besides, the mRNA expression levels of TIMP-3 and col1a1 were decreased, while that of iNOS increased. Thus, levofloxacin induced apoptosis and unbalanced MMPs/TIMPs expression in meniscus cells.

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