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Qingyu Huang, Jie Zhang, Siyuan Peng, Meiping Tian, Jinsheng Chen and Heqing Shen Effects of water soluble PM2.5 extracts exposure on human lung epithelial cells (A549): A proteomic study Journal of Applied Toxicology 34

Version of Record online: 14 AUG 2013 | DOI: 10.1002/jat.2910

Airborne particulate matter (PM)2.5 exposure has been associated with a number of adverse health effects. However, the mechanisms underlying PM2.5 toxicity remain unclear. In the current proteomic study, 22 differentially expressed proteins responsive to water-soluble PM2.5 extract treatment in A549 cells were identified by 2-D difference gel electrophoresis and matrix-assisted laser desorption/ionization time-of-flight tandem mass spectrometry. Furthermore, induction of apoptosis was proposed as a vital mechanism for water-soluble PM2.5 extract cytotoxicity. These results may provide useful insights into the mechanisms of PM2.5 toxicity and assist in the development of biomarkers of PM2.5 exposure.

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