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Bing Yang, Jing Huang, Tingxiu Xiang, Xuedong Yin, Xinrong Luo, Jianbo Huang, Fuling Luo, Hongyuan Li, Hongzhong Li and Guosheng Ren Chrysin inhibits metastatic potential of human triple-negative breast cancer cells by modulating matrix metalloproteinase-10, epithelial to mesenchymal transition, and PI3K/Akt signaling pathway Journal of Applied Toxicology 34

Version of Record online: 10 OCT 2013 | DOI: 10.1002/jat.2941

The effect and mechanisms of chrysin on cancer metastasis still remain enigmatic. In this study, metastatic triple-negative breast cancer (TNBC) cell lines were used to evaluate the anti-metastatic acitivity of chrysin. The results showed that chrysin significantly suppressed TNBC cell migration and invasion in a dose-dependent manner. It was demonstrated that inhibiting Akt signaling pathway might play a central role in chrysin-induced anti-metastatic activity by regulating MMP-10 and EMT.

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