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M. E. Meek, A. Boobis, I. Cote, V. Dellarco, G. Fotakis, S. Munn, J. Seed and C. Vickers New developments in the evolution and application of the WHO/IPCS framework on mode of action/species concordance analysis Journal of Applied Toxicology 34

Version of Record online: 25 OCT 2013 | DOI: 10.1002/jat.2949

The World Health Organization/International Programme on Chemical Safety mode of action/human relevance framework has been updated to reflect experience acquired in its application and extend its utility to emerging areas in toxicity testing and non-testing methods. This modified framework and accompanying roadmap and case examples are expected to contribute to improving transparency in explicitly addressing weight of evidence considerations in mode of action/species concordance analysis based on both conventional data sources and evolving methods.

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