Haiyan Xie, Pontus Svenmarker, Johan Axelsson, Susanna Gräfe, Maria Kyriazi, Niels Bendsoe, Stefan Andersson-Engels and Katarina Svanberg Pharmacokinetic and biodistribution study following systemic administration of Fospeg® – a Pegylated liposomal mTHPC formulation in a murine model Journal of Biophotonics 8
In this study the pharmacokinetics and biodistribution of the photosensitizer Fospeg are investigated in mice inoculated with HT29 colon tumors. High performance liquid chromatography indicates a higher plasma peak concentration, alonger circulation time and a better tumor-to-skin ratio than those of Foslip. Good correlation between the ex vivo fluorescence and reflectance imaging and chemical extraction data shows that optical imaging provides the potential for fluorophore quantification in biological tissues.
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