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Eamonn Kennedy, Rasoul Al-Majmaie, Mohamed Al-Rubeai, Dominic Zerulla and James H. Rice Quantifying nanoscale biochemical heterogeneity in human epithelial cancer cells using combined AFM and PTIR absorption nanoimaging Journal of Biophotonics 8

Version of Record online: 8 NOV 2013 | DOI: 10.1002/jbio.201300138

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The biomechanics underlying the structure-function relationship is governed by cell substructures which are poorly resolved using conventional chemical imaging methods. Advances in subdiffraction limited infrared (IR) nanoscopy have permitted intracellular chemical mapping. This work reports how image analysis applied to a combination of IR absorption nanoimaging and topographic data permits quantification of chemical complexity at the nanoscale, enabling the analysis of biochemical heterogeneity in mammalian cancer cells on the scale of subcellular features.

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