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Sergiy Patskovsky, Eric Bergeron and Michel Meunier Hyperspectral darkfield microscopy of PEGylated gold nanoparticles targeting CD44-expressing cancer cells Journal of Biophotonics 8

Version of Record online: 17 DEC 2013 | DOI: 10.1002/jbio.201300165

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A new hyperspectral darkfield imaging system with a scanned broadband supercontinuum light source is presented. The specific attachment of functionalized gold nanoparticles targeting CD44+ cancer cells by conventional and by proposed hyperspectral darkfield microscopy is observed. This wide-field and low phototoxic system allows spectral 3D localization and spectroscopic identification of nanoparticles in a complex cellular environment. Such information is essential for the improvement of imaging, detection and treatment of diseases.

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