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Hugh Sparks, Sean Warren, Joana Guedes, Nagisa Yoshida, Tze Choong Charn, Nadia Guerra, Taranjit Tatla, Christopher Dunsby and Paul French A flexible wide-field FLIM endoscope utilising blue excitation light for label-free contrast of tissue Journal of Biophotonics 8

Version of Record online: 27 FEB 2014 | DOI: 10.1002/jbio.201300203

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Fluorescence lifetime imaging (FLIM) has previously been shown to provide contrast between normal and diseased tissue. The study presents progress towards clinical and preclinical FLIM endoscopy of tissue autofluorescence, demonstrating a flexible wide-field endoscope that utilised a low average power blue picosecond laser diode excitation source and was able to acquire ~mm-scale spatial maps of autofluorescence lifetimes from fresh ex vivo diseased human larynx biopsies in ~8 seconds using an average excitation power of ~0.5 mW at the specimen.

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