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Zac Long, Jeff Maltas, Michael C. Zatt, Jun Cheng, Erik J. Alquist, Alex Brest and Paul Urayama The real-time quantification of autofluorescence spectrum shape for the monitoring of mitochondrial metabolism Journal of Biophotonics 8

Version of Record online: 14 MAR 2014 | DOI: 10.1002/jbio.201300207

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The cellular proportion of free and protein-bound NADH complexes is increasingly recognized as a metabolic indicator and biomarker. Because free and bound forms exhibit different fluorescence spectra, it is considered whether autofluorescence shape sufficiently correlates with mitochondrial metabolism to be useful for monitoring in cellular suspensions. Observed changes appear consistent with previous studies probing free/protein-bound proportions, making this a potentially useful approach for the real-time monitoring of metabolism.

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