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Cover Image, Volume 34, Issue 10 Journal of Computational Chemistry 34

Version of Record online: 14 MAR 2013 | DOI: 10.1002/jcc.23274

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Erythropoeitin (Epo) is a treatment for anemia that elicits an immune response in some patients. The figure (from pdb id 1eer, rendered by PyMol) shows Epo (ribbon) and its receptor (surface), highlighting by color and ribbon thickness the locations of predicted T-cell epitopes within Epo. The computational method by Yoonjoo Choi, Karl E. Griswold, and Chris Bailey-Kellogg on page 879 redesigns such therapeutic proteins so as to have minimal predicted T-cell epitope content but still maintain native-like structural and sequence properties.

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