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Ariel A. Petruk and Rosa María S. Álvarez Structural changes induced by interactions between thyroid hormones and phospholipid membranes: a Raman Spectroscopy study Journal of Raman Spectroscopy 44

Version of Record online: 13 NOV 2012 | DOI: 10.1002/jrs.4205

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Interactions of T2, T3, and T4 with a model membrane of dilauroylphosphatidylcholine in the liquid-crystalline phase were analyzed by Raman spectroscopy. Insights into the nature of the hormone effects on the membrane properties, as well the structural adaptations of the hormones in response to the lipid environment were derived from the spectral changes. The series of progressive iodine substituents on the ring-β allowed to correlate the hormone effects according to the number of the iodine atoms.

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