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J. A. Anastasopoulos, A. Soto Beobide and G. A. Voyiatzis Quantitative surface enhanced Raman scattering measurements at the early stage of active agent release processes Journal of Raman Spectroscopy 44

Version of Record online: 27 DEC 2012 | DOI: 10.1002/jrs.4222

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The surface enhanced Raman scattering spectroscopy (SERS) is introduced as a new method to probe the initial release of active agents from controlled delivery systems. Surface enhanced resonance Raman scattering measurements of mitoxantrone allowed the quantitative delineation of the initial drug release profile, and the technique has proved as a highly sensitive method to quantitatively monitor the initial release of the medicine even at the very early stage of the delivery process.

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