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Suneetha Devpura, Jagdish S. Thakur, Janet M. Poulik, Rajah Rabah, Vaman M. Naik and Ratna Naik Raman spectroscopic investigation of frozen and deparaffinized tissue sections of pediatric tumors: neuroblastoma and ganglioneuroma Journal of Raman Spectroscopy 44

Article first published online: 21 NOV 2012 | DOI: 10.1002/jrs.4223

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We have investigated neuroblastoma and ganglioneuroma using Raman spectroscopy and compared their spectral characteristics with those of normal adrenal gland. The frozen sections of normal adrenal gland tissues show higher levels of carotenoids, lipids, and cholesterol compared with the neuroblastoma and ganglioneuroma tissues. Preservation of tissues using formalin and paraffin leads to removal of carotenoids, lipids, and cholesterol in adrenal tissues. The study shows that Raman spectroscopy in conjunction with chemometric methods can be used to distinguish neuroblastoma and ganglioneuroma.

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