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C. M. B. Santos, S. W. da Silva, C. A. Saldanha, M. F. M. Almeida Santos, M. P. Garcia, R. B. Azevedo and P. C. Morais SERS as a valuable tool for detection and treatment follow-up of fungal infection in mice lungs: use of Amphotericin B and its nanoencapsulation onto magnetic nanoparticles Journal of Raman Spectroscopy 44

Article first published online: 25 FEB 2013 | DOI: 10.1002/jrs.4259

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Analysis of surface-enhanced Raman scattering spectra recorded in tissue samples collected from the lungs of Paracoccidioidomycosis-infected and non-infected mice provided information regarding the therapeutic response while using magnetic nanoparticles surface functionalized with Amphotericin B (AmB) and free AmB. It was found that both AmB-based treatments lead to the same result, although NP-Amp carries substantially lower (40%) drug doses

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