E-mail

E-mail a Wiley Online Library Link

Irene Izquierdo-Lorenzo, José Vicente García-Ramos and Santiago Sanchez-Cortes Vibrational characterization and surface-enhanced Raman scattering detection of probenecid doping drug Journal of Raman Spectroscopy 44

Article first published online: 5 APR 2013 | DOI: 10.1002/jrs.4284

Thumbnail image of graphical abstract

We report the detection by SERS of Probenecid, a drug employed to reduce the excretion of other drugs in urine and also employed as masking agent in sport doping. A previous vibrational study was done by FTIR, FT-Raman and DFT calculations. The experimental conditions of SERS measurement were optimized by varying parameters like the metal, its reduction protocol to fabricate the nanoparticles and the pH. The adsorption isotherms of PB on the metal nanoparticles were obtained and the adsorption mechanism of this drug on Ag nanoparticles was deduced from the analysis of SERS spectra. Finally, a quantitative SERS study was carried out on the basis of the calibration curve deduced from the adsorption isotherms.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field

SEARCH