Froukje L. J. Cals, Tom C. Bakker Schut, Senada Koljenović, Gerwin J. Puppels and Robert J. Baatenburg de Jong Method development: Raman spectroscopy-based histopathology of oral mucosa Journal of Raman Spectroscopy 44
The described method is based on Raman microspectroscopic mapping of unstained frozen tissue sections and subsequent histopathological annotation of the features in the resulting pseudocolor Raman images. The obtained annotated reference spectra were used as input in an HCA in order to determine the spectral characteristics and variance of individual histo(patho)logical structures in oral mucosa. This information can be used for the development of classification and quantification algorithms, in order to improve specificity and sensitivity of clinical diagnostic instruments.
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