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Aijing Wang, Weidong Ruan, Wei Song, Lei Chen, Bing Zhao, Young Mee Jung and Xu Wang Detection of the potential tumor marker of AFP using surface-enhanced Raman scattering-based immunoassay Journal of Raman Spectroscopy 44

Article first published online: 30 SEP 2013 | DOI: 10.1002/jrs.4391

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In this paper, we propose a universal, rapid, sensitive, and highly specific immunoassay system utilizing gold nanoparticles (AuNPs) and surface-enhanced Raman scattering (SERS). This new system features a sandwich structure combining mercaptobenzoic acid-labeled immunogold nanoparticles with the antigen and the antibody atop a pre-designed substrate made of a glass slide modified with AuNPs. This SERS-based immunoassay can detect AFP concentrations as low as 100 pg/ml, which is a significant improvement on the capabilities of the enzyme-linked immunosorbent assay method. This technique provides an effective model for the detection of biomarkers in medical diagnostics, criminal investigation, and other fields.

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