Tran Thi Bich Quyen, Wei-Nien Su, Kuan-Jung Chen, Chun-Jern Pan, John Rick, Chun-Chao Chang and Bing-Joe Hwang Au@SiO2 core/shell nanoparticle assemblage used for highly sensitive SERS-based determination of glucose and uric acid Journal of Raman Spectroscopy 44
Rhodamine 6G was used to evaluate the surface-enhanced Raman scattering (SERS) enhancement for the synthesized Au@SiO2 core/shell nanoparticles with various silica shell thicknesses. The SERS signal from Rhodamine 6G was found be the highest on Au@SiO2 with a silica layer of 1–2 nm. Our results show that the SERS technique is able to detect glucose and uric acid within wide concentration ranges, i.e. 20 ng/dL to 20 mg/dL (10−12–10−3 M) and 16.8 ng/dL to 2.9 mg/dL (10−11–1.72 × 10−4 M), respectively.
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