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Freeborn Rwere, Piotr J. Mak and James R. Kincaid Resonance Raman determination of vinyl group disposition in different derivatives of native myoglobin and its heme-disoriented form Journal of Raman Spectroscopy 45

Version of Record online: 2 JAN 2014 | DOI: 10.1002/jrs.4419

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Resonance Raman spectroscopy is used to interrogate the relative orientations of the two peripheral vinyl groups of the heme in the met-, deoxy-, and ferrous CO adducts of horse heart myoglobin in the native form and that bearing a reversed heme conformation. Specifically, a protoheme that is deuterated only at the 4-vinyl group provides a spectral editing mechanism for selectively tracking the disposition of the individual vinyl groups. This is important because vinyl group orientation can impact protein function.

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