Alberto Lanz-Landázuri, Montserrat García-Alvarez, José Portilla-Arias, Antxon Martínez de Ilarduya, Rameshwar Patil, Eggehard Holler, Julia Y. Ljubimova and Sebastián Muñoz-Guerra Poly(methyl malate) Nanoparticles: Formation, Degradation, and Encapsulation of Anticancer Drugs Macromolecular Bioscience 11
Nanoparticles of poly(β,L-malic acid) methyl ester with average diameters of 150–250nm are prepared by emulsion evaporation. They degrade under physiological conditions, producing L-malic acid and methanol as the final products. When used as drug delivery system, doxorubicin is steadily released from the NPs over 1 month, whereas temozolomide is fully liberated in a few hours.
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