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Stefanie U. Frick, Nicole Bacher, Grit Baier, Volker Mailänder, Katharina Landfester and Kerstin Steinbrink Functionalized Polystyrene Nanoparticles Trigger Human Dendritic Cell Maturation Resulting in Enhanced CD4+ T Cell Activation Macromolecular Bioscience 12

Version of Record online: 5 OCT 2012 | DOI: 10.1002/mabi.201200223

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Sulfonate- and phosphonate-functionalized polystyrene nanoparticles exhibit a pronounced uptake by immature and mature dendritic cells compared to unfunctionalized nanoparticles. Moreover, sulfonated and phosphonated polystyrene nanoparticles trigger iDC maturation accompanied with a strengthened CD4+ T cell stimulatory capacity and elevated IFN-γ levels, indicating a Th1 response.

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