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Nikken Wiradharma, Melvin Y. S. Sng, Majad Khan, Zhan-Yuin Ong and Yi-Yan Yang Rationally Designed α-Helical Broad-Spectrum Antimicrobial Peptides with Idealized Facial Amphiphilicity Macromolecular Rapid Communications 34

Version of Record online: 30 OCT 2012 | DOI: 10.1002/marc.201200534

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A series of 12-amino acid peptide analogues has been designed with uninterrupted hydrophobic/cationic helical faces based on the α-helical protein folding principle. The peptides with perfectly uninterrupted hydrophobic and cationic faces provide optimal activity and selectivity towards a wide range of Gram-positive, Gram-negative bacteria and yeast.

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