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Christian Geraths, Erik H. Christen and Wilfried Weber A Hydrogel Sensing Pathological Urate Concentrations Macromolecular Rapid Communications 33

Version of Record online: 19 OCT 2012 | DOI: 10.1002/marc.201200563

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A stimulus-responsive biohybrid material is described that rapidly dissolves at pathological concentrations of the gouty arthritis-causing metabolite urate. The gel consists of polyacrylamide and DNA that are crosslinked by the Deinococcus radiodurans-derived urate sensor HucR, which binds its specific target DNA motif at physiological urate concentrations and dissociates thereof at pathological concentrations.

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