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Xuejuan Wan, Tao Liu, Jinming Hu and Shiyong Liu Photo-Degradable, Protein–Polyelectrolyte Complex-Coated, Mesoporous Silica Nanoparticles for Controlled Co-Release of Protein and Model Drugs Macromolecular Rapid Communications 34

Version of Record online: 6 DEC 2012 | DOI: 10.1002/marc.201200673

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Decomposable protein–polyelectrolyte complexes (PPCs) formed by the protein bovine serum albumin (BSA) and charge reversible polymers are utilized as a novel strategy towards the on/off switching of nanopore entrances on mesoporous silica nanoparticles (MSNs). Under photo-irradiation, disruption of the PPC coating on MSNs can lead to the co-release of BSA and loaded rhodamine B.

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