Dong Ma, Zong-Hua Liu, Qian-Qian Zheng, Xiao-Yan Zhou, Yi Zhang, Yun-Feng Shi, Jian-Tao Lin and Wei Xue Star-Shaped Polymer Consisting of a Porphyrin Core and Poly(L-lysine) Dendron Arms: Synthesis, Drug Delivery, and In Vitro Chemo/Photodynamic Therapy Macromolecular Rapid Communications 34
A star-shaped polymer consisting of a porphyrin core and poly(L-lysine) dendron arms is synthesized and used for doxorubicin delivery. As shown, the drug-loaded complex is uptaken easily by CNE2 cells. In vitro toxicity assay confirms that the complexes shows a higher cytotoxicity under the light condition than polymer or doxorubicin alone, suggesting a potential application in combined photodynamic therapy and chemotherapy.
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