Sharan Ramaswamy, Paul A. Schornack, Adam G. Smelko, Steven M. Boronyak, Julia Ivanova, John E. Mayer Jr and Michael S. Sacks Superparamagnetic iron oxide (SPIO) labeling efficiency and subsequent MRI tracking of native cell populations pertinent to pulmonary heart valve tissue engineering studies NMR in Biomedicine 25
Migration of vascular cells is an attribute contributing to pulmonary heart valve remodeling. This process is of interest in the context of tissue engineered heart valve implantation. As a first step in studying the remodeling events, the scope of this work was to determine if vascular cells distributed in in vitro engineered tissue constructs could be effectively labeled with superparamagnetic iron oxide microparticles, followed by visualization and tracking by magnetic resonance imaging.
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