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Franziska Weber, Julia Böhme, Holger A. Scheidt, Wilfried Gründer, Stefan Rammelt, Michael Hacker, Michaela Schulz-Siegmund and Daniel Huster 31P and 13C solid-state NMR spectroscopy to study collagen synthesis and biomineralization in polymer-based bone implants NMR in Biomedicine 25

Article first published online: 12 JAN 2011 | DOI: 10.1002/nbm.1649

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We used a combination of solid-state NMR spectroscopy and MRI to evaluate the formation of extracellular matrix in poly(D,L-lactide-co-glycolide) bone implants. In addition to the images, we used magic angle spinning NMR to analyse the collagen (by 13C NMR) and apatite (by 31P NMR) formed in the implants. This analysis provides useful information on the composition and structure of the extracellular matrix, and serves as a tool for the evaluation of the quality of tissue engineering.

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