Maria T. Grinde, Siver A. Moestue, Eldrid Borgan, Øystein Risa, Olav Engebraaten and Ingrid S. Gribbestad 13C High-resolution-magic angle spinning MRS reveals differences in glucose metabolism between two breast cancer xenograft models with different gene expression patterns NMR in Biomedicine 24
13C high-resolution-magic angle spinning (HR-MAS) MRS and gene expression analysis were performed to study the glycolytic activity in two breast cancer xenograft models representing basal-like and luminal-like genetic profiles. 13C HR-MAS MRS was performed both on untreated mice and a group of mice that received an injection of [1-13C]-glucose 10 or 15min before harvesting the tissue. The lower glucose/alanine and glucose/lacate ratios and higher glycolytic gene expression observed in the luminal-like model indicated that transformation of glucose to lactate and alanine occurred faster in this model than in the basal-like model, which has a growth rate several times faster than that of the luminal-like model.
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