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Xingchen Wu, Pirkko-Liisa Kellokumpu-Lehtinen, Hannu Pertovaara, Pasi Korkola, Seppo Soimakallio, Hannu Eskola and Prasun Dastidar Diffusion-weighted MRI in early chemotherapy response evaluation of patients with diffuse large B-cell lymphoma – a pilot study: comparison with 2-deoxy-2-fluoro- D-glucose-positron emission tomography/computed tomography NMR in Biomedicine 24

Version of Record online: 8 MAR 2011 | DOI: 10.1002/nbm.1689

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Eight patients with aggressive non-Hodgkin's lymphoma were imaged by MRI, including diffusion-weighted imaging, and positron emission tomography/computed tomography (PET/CT) before treatment (E1), and after 1 week (E2) and two cycles (E3) of chemotherapy. The mean pre-therapy apparent diffusion coefficient (ADC) was 0.71 × 10–3 mm2/s; it increased by 77% at E2 (p<0.05) and 24% more at E3. The results of DWI in combination with whole-body MRI were found to be comparable with those of integrated PET/CT.

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