David A. Reiter, Remigio A. Roque, Ping-Chang Lin, Stephen B. Doty, Nancy Pleshko and Richard G. Spencer Improved specificity of cartilage matrix evaluation using multiexponential transverse relaxation analysis applied to pathomimetically degraded cartilage NMR in Biomedicine 24
We sought to improve the specificity of cartilage matrix evaluation through multiexponential analysis of T2 relaxation, which can delineate macromolecular compartments with different water fraction and mobilies. Multiexponential T2 analysis of control cartilage and of cartilage subjected to two enzymatic degradation protocols showed distinct patterns, consistent with the known actions of the degradative enzymes used. Multiexponential T2 analysis demonstrates greatly improved specificity over standard monoexponential T2 analysis to changes in cartilage matrix, indicating its diagnostic potential for the detection of cartilage disease.
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