Emeline J. Ribot, Sylvain Miraux, Jan P. Konsman, Véronique Bouchaud, Line Pourtau, Marie-Hélène Delville, Jean-Michel Franconi, Eric Thiaudière and Pierre J. Voisin In vivo MR tracking of therapeutic microglia to a human glioma model NMR in Biomedicine 24
Microglia can be used as a therapeutic vehicle to transport the thymidine kinase gene and gadolinium-based silica nanoparticles into brain tumors. In vivo MRI shows that, as soon as 24 h after systemic injection, contrast agent-labeled microglia are efficiently chemoattracted to human glioma implanted in the brains of nude mice. Systemic injection of a thymidine kinase substrate induces a significantly prolonged survival time of the mice.
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