Gary V. Martinez, Xiaomeng Zhang, María L. García-Martín, David L. Morse, Mark Woods, A. Dean Sherry and Robert J. Gillies Imaging the extracellular pH of tumors by MRI after injection of a single cocktail of T1 and T2 contrast agents NMR in Biomedicine 24
A single-infusion protocol consisting of the slow infusion of a contrast agent cocktail yielded high-resolution extracellular pH (pHe) maps of tumors. The current method is based on a calibration between [Gd] derived from T1-weighted spin echo and ΔR2*. The primary advantage of this protocol over previous studies is the rapidity of generating the pHe measurement after the calibration curve has been obtained.
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