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Kejia Cai, Adam Shore, Anup Singh, Mohammad Haris, Teruyuki Hiraki, Prianka Waghray, Damodar Reddy, Joel H. Greenberg and Ravinder Reddy Blood oxygen level dependent angiography (BOLDangio) and its potential applications in cancer research NMR in Biomedicine 25

Version of Record online: 2 FEB 2012 | DOI: 10.1002/nbm.2780

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Longitudinal monitoring of tumor angiogenesis can help clinicians determine the effectiveness of anti-angiogenic therapy. Blood Oxygen Level Dependent angiography (BOLDangio) represents a novel application of BOLD MRI. In this study, oxygen inhalation levels are optimized to enable us to image/quantify the normal or tumor vasculature at a high resolution, detect tumor metastasis and tumor associated hemorrhage. BOLDangio may be used to as a powerful preclinical research tool for monitoring the treatment responses of anti-angiogenic therapies.

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