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J. A. Wells, B. Siow, M. F. Lythgoe and D. L. Thomas The importance of RF bandwidth for effective tagging in pulsed arterial spin labeling MRI at 9.4T NMR in Biomedicine 25

Article first published online: 19 APR 2012 | DOI: 10.1002/nbm.2782

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This study highlights a potential source of error in cerebral blood flow quantification using PASL at high field. We demonstrate that the labelling efficiency in flow-sensitive alternating inversion recovery (FAIR) displays marked sensitivity to the RF bandwidth of the inversion pulse in the rat at 9.4T. It is likely that this potential problem may have otherwise escaped consideration in future studies given that: i) it has not been previously investigated; ii) the lack of obvious symptoms presented other than a lower than expected CBF; iii) the dependence of the necessary bandwidth for efficient inversion on the slice position (i.e. what appears to be adequate for one slice may be problematic in another).

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