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Anna V. Naumova, Vasily L. Yarnykh, Niranjan Balu, Hans Reinecke, Charles E. Murry and Chun Yuan Quantification of MRI signal of transgenic grafts overexpressing ferritin in murine myocardial infarcts NMR in Biomedicine 25

Article first published online: 24 FEB 2012 | DOI: 10.1002/nbm.2788

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Transgenic C2C12 grafts overexpressing ferritin were detected in infarcted mouse heart as areas of hypointensity in T2*-weighted black-blood improved motion-sensitized-driven equilibrium (iMSDE) and bright-blood gradient echo (GRE) sequences using a 3-T scanner; the signal intensity ratio was reduced significantly by 20% and 30%, respectively. Unlabeled cells transplanted to mouse heart did not change the MRI signal intensity. MRI graft size measurements were highly correlated with histology (r = 0.79 for T2* iMSDE and r = 0.89 for T2* GRE)

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