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Xiaojie Wang, Joan K. Brieland, Joong H. Kim, Ying-Jr Chen, Janet O'Neal, Shawn P. O'Neil, Tsang-Wei Tu, Kathryn Trinkaus and Sheng-Kwei Song Diffusion tensor imaging detects treatment effects of FTY720 in experimental autoimmune encephalomyelitis mice NMR in Biomedicine 26

Article first published online: 12 AUG 2013 | DOI: 10.1002/nbm.3012

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Prophylactic administration of FTY720 prevented axon and myelin damage when compared with EAE mice without treatment. Therapeutic treatment of FTY720 reduced the disease severity, improving the axial and radial diffusivity towards the control values without statistical significance. The in vivo DTI-derived axial and radial diffusivity correlated with clinical scores in EAE mice. The results support the use of in vivo DTI as an effective outcome measure for preclinical drug development.

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