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Dr. Friederike Fehr, Dr. André Nadler, Dr. Florian Brodhun, Prof. Dr. Ivo Feussner and Prof. Dr. Ulf Diederichsen Semi-Synthesis and Analysis of Chemically Modified Zif268 Zinc-Finger Domains ChemistryOpen 1

Article first published online: 2 JAN 2012 | DOI: 10.1002/open.201100002

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The entire zinc-finger domain of Zif268 was synthesized by a semi-synthetic pathway using the expressed protein ligation approach. Despite several modifications, for example, attachment of a fluorophore and introduction of a metal-chelating amino acid within the sequence of the third zinc finger, circular dichroism spectroscopic measurements confirmed zinc-induced folding and intact DNA binding ability.

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