Rubén Ferreira, Dr. Margarita Alvira, Dr. Anna Aviñó, Dr. Irene Gómez-Pinto, Dr. Carlos González, Dr. Valérie Gabelica and Dr. Ramon Eritja Synthesis and Structural Characterization of Stable Branched DNA G-Quadruplexes Using the Trebler Phosphoramidite ChemistryOpen 1
Tuning the treble! Herein, we describe a method to prepare highly stable G-quadruplexes by linking four guanine (G)-rich DNA strands on one end. This approach allows the introduction of specific modifications in one of the strands. For instance, we prepared a quadruplex with a single antiparallel strand. In this case, all-parallel or 3+1 structures are observed depending on the cation present. In addition to the expected monomolecular species, we observed the presence of dimeric G-quadruplex structures.
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