E-mail a Wiley Online Library Link

Dr.  Edmund J. Keliher, Dr.  Thomas Reiner, Dr.  Greg M. Thurber, Rabi Upadhyay and Prof.  Ralph Weissleder Efficient 18F-Labeling of Synthetic Exendin-4 Analogues for Imaging Beta Cells ChemistryOpen 1

Version of Record online: 31 JUL 2012 | DOI: 10.1002/open.201200014

Thumbnail image of graphical abstract

Clicked in place: Based on the trans- cyclooctene/tetrazine cycloaddition, we labeled an exendin-4 derivative with 18F. The resulting PET tracer accumulated in both pancreatic beta cells as well as in different murine xenografts of insulinomas, and uptake could be inhibited by unlabeled exendin-4. Based on pharmacokinetic modeling, the plasma clearance and tracer uptake data obtained from these experiments were used to extrapolate our findings to humans for clinical translation.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field