Dr. Thomas Reiner, Dominik Jantke, Dr. Alexander N. Marziale, Andreas Raba and Prof. Jörg Eppinger Metal-Conjugated Affinity Labels: A New Concept to Create Enantioselective Artificial Metalloenzymes ChemistryOpen 2
How to train a protein: Metal-conjugated affinity labels were used to selectively position catalytically active metal centers in the binding pocket of proteases. The resulting artificial metalloenzymes achieve up to 82 % e.r. in the hydrogenation of ketones. The modular setup enables a rapid generation of artificial metalloenzyme libraries, which can be adapted to a broad range of catalytic conditions.
Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf