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Dr. Thomas Reiner, Dominik Jantke, Dr. Alexander N. Marziale, Andreas Raba and Prof. Jörg Eppinger Metal-Conjugated Affinity Labels: A New Concept to Create Enantioselective Artificial Metalloenzymes ChemistryOpen 2

Version of Record online: 20 FEB 2013 | DOI: 10.1002/open.201200044

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How to train a protein: Metal-conjugated affinity labels were used to selectively position catalytically active metal centers in the binding pocket of proteases. The resulting artificial metalloenzymes achieve up to 82 % e.r. in the hydrogenation of ketones. The modular setup enables a rapid generation of artificial metalloenzyme libraries, which can be adapted to a broad range of catalytic conditions.

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