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Kathrin Wähler, Katja Kräling, Dr. Holger Steuber and Prof. Dr. Eric Meggers Non-ATP-Mimetic Organometallic Protein Kinase Inhibitor ChemistryOpen 2

Version of Record online: 5 SEP 2013 | DOI: 10.1002/open.201300031

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Non-hinge binding: A novel organometallic protein kinase inhibitor scaffold based on a cyclometalated 1,8-phenanthrolin-7(8 H)-one ligand is reported, which binds to the ATP binding site of the protein kinase Pim1 in an unexpected, unusual non-ATP-mimetic fashion without mimicking the hydrogen-bonding interaction of the adenine nucleobase of ATP.

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