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Dr. Brian M. Zeglis, Fabien Emmetiere, Dr. Nagavarakishore Pillarsetty, Prof. Ralph Weissleder, Prof. Jason S. Lewis and Prof. Thomas Reiner Building Blocks for the Construction of Bioorthogonally Reactive Peptides via Solid-Phase Peptide Synthesis ChemistryOpen 3

Article first published online: 6 APR 2014 | DOI: 10.1002/open.201402000

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The earlier, the better! We report a novel synthesis of tetrazine-functionalized artificial amino acids, the creation of a model tetrazine-containing pentapeptide using solid-phase peptide synthesis, and the facile and rapid bioorthogonal radiolabeling of this peptide using a 89Zr-desferrioxamine-labeled trans-cyclooctene.

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