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Kevin Spencer and Nicholas J. Cowans Correction of first trimester biochemical aneuploidy screening markers for smoking status: influence of gestational age, maternal ethnicity and cigarette dosage Prenatal Diagnosis 33

Article first published online: 20 NOV 2012 | DOI: 10.1002/pd.4017

What's already known about this topic?

  • First trimester screening markers PAPP-A and free hCGβ are reduced in smokers and are corrected for by using universal correction factors.

What does this study add?

  • Gestational age, maternal ethnicity and cigarette dosage all appear to influence the extent of reduction of these marker levels in smokers.
  • A more complex correction system may be required.

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