Kevin Spencer and Nicholas J. Cowans Correction of first trimester biochemical aneuploidy screening markers for smoking status: influence of gestational age, maternal ethnicity and cigarette dosage Prenatal Diagnosis 33
What's already known about this topic?
- First trimester screening markers PAPP-A and free hCGβ are reduced in smokers and are corrected for by using universal correction factors.
What does this study add?
- Gestational age, maternal ethnicity and cigarette dosage all appear to influence the extent of reduction of these marker levels in smokers.
- A more complex correction system may be required.
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