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Anne Sørensen, David Peters, Carsten Simonsen, Michael Pedersen, Brian Stausbøl-Grøn, Ole Bjarne Christiansen, Göran Lingman and Niels Uldbjerg Changes in human fetal oxygenation during maternal hyperoxia as estimated by BOLD MRI Prenatal Diagnosis 33

Article first published online: 12 DEC 2012 | DOI: 10.1002/pd.4025

What's already known about this topic?

  • The BOLD MRI signal depends upon the magnetic properties of hemoglobin.
  • In the sheep fetus, changes in the BOLD MRI signal reflect changes in fetal tissue oxygenation.
  • Maternal hyperoxia increases the fetal oxygen supply when estimated by cordocentesis.

What does this study add?

  • In the human fetus, the BOLD technique is capable of measuring changes in tissue oxygenation in various fetal organs.
  • Maternal hyperoxia increases fetal tissue oxygenation in a number of fetal organs.
  • The oxygenation of the fetal brain is unaffected by maternal hyperoxia, this could be caused by autoregulation of fetal cerebral bloodflow – reversed brain sparing.

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