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Margherita Zanello, Paola DeSanctis, Giulia Pula, Cinzia Zucchini, Maria Carla Pittalis, Nicola Rizzo and Antonio Farina Circulating mRNA for epidermal growth factor-like domain 7 (EGFL7) in maternal blood and early intrauterine growth restriction. A preliminary analysis Prenatal Diagnosis 33

Version of Record online: 26 DEC 2012 | DOI: 10.1002/pd.4034

What's already known about this topic?

  • EGFL7 is expressed during intense vasculogenesis and during embryonic development. During pregnancy, EFGL7 gene expression has been found to be decreased in placental tissues of pregnancies complicated by early onset pre-eclampsia.

What does this study add?

  • This paper is the first that reports dosage of mRNA for EGFL7 in maternal blood from pregnancies affected with severe early IUGR.
  • We have found high levels of this mRNA in IUGR when compared with controls matched for gestational age and fetal gender.

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