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M. Grande, E. Ordoñez, V. Cirigliano, J. Cid, E. Grau, A. Pericot, I. Teixido, J. L. Marin and A. Borrell Clinical application of midtrimester non-invasive fetal RHD genotyping and identification of RHD variants in a mixed-ethnic population Prenatal Diagnosis 33

Article first published online: 20 DEC 2012 | DOI: 10.1002/pd.4035

What's already known about this topic?

  • Routine antenatal RHD genotyping performed in maternal plasma by real-time PCR is an accurate method to avoid the use of anti-D immunoglobulin when both the pregnant woman and the fetus are RhD negative.

What does this study add?

  • Fetal genotyping at 24 weeks of gestation is highly accurate using probes for RHD exons 5 and 7 (10 and 6 in selected cases), minimizing the false negative results and allowing prenatal detection of RHD variants in our mixed ethnic population.

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